Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

356
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
356
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

353
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
353
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

277
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
277
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

8.4K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of Energy Sources in Surgical Ablation of Atrial Fibrillation: Current Technology and Future Directions.

Reviews in cardiovascular medicine·2026
Same author

Peculiarities of Phosphatidylserine Externalization by Nano- and Microsecond Electric Pulses.

The Journal of membrane biology·2026
Same author

Noninvasive optogenetic induction of cardiac arrhythmias alters systemic hemodynamics in mice.

Science advances·2026
Same author

Establishment and Histopathological Characterization of a KYSE-30 Subcutaneous Xenograft Model of Esophageal Squamous Cell Carcinoma.

Cancers·2026
Same author

Sub-microsecond optical measurements of cell membrane charging and lesioning by pulsed electric fields.

Bioelectrochemistry (Amsterdam, Netherlands)·2026
Same author

Mechanisms of atrial fibrillation in mitral regurgitation patients: Insights from noninvasive electrocardiographic imaging.

Journal of electrocardiology·2026
Same journal

A Roadmap for Bioelectric Electrochemical Sensing in Cancer.

Bioelectricity·2026
Same journal

MEB: "From Development to Cognitive Glue: My Journey in Bioelectricity".

Bioelectricity·2026
Same journal

Inhibiting Metastasis Through Ion Channels: Combinatorial Treatment in accordance with the CELEX Model?

Bioelectricity·2026
Same journal

Exploring Sub-Microsecond Plasma Membrane Potential Shifts and Bioeffects Under Low-Energy Electric Pulse Stimulation.

Bioelectricity·2026
Same journal

Investigating the Role of Water Molecules in TRPV4 Ion Channels Under Intense Electric Fields Using Molecular Dynamics Simulations.

Bioelectricity·2026
Same journal

<i>Bioelectricity</i> in Health Care.

Bioelectricity·2026
See all related articles

Related Experiment Video

Updated: Dec 14, 2025

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.7K

Using Nanosecond Shocks for Cardiac Defibrillation.

Johanna U Neuber1,2, Frency Varghese3, Andrei G Pakhomov1

  • 1Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia.

Bioelectricity
|July 21, 2020
PubMed
Summary
This summary is machine-generated.

Nanosecond shocks show promise for cardiac defibrillation, using less energy than millisecond shocks. While single shocks appear safe, repeated nanosecond pulse stimulation may harm heart cells and disrupt calcium signaling.

Keywords:
arrhythmiacardiacdefibrillationnanosecond

More Related Videos

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

673
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

16.2K

Related Experiment Videos

Last Updated: Dec 14, 2025

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

2.7K
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

673
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

16.2K

Area of Science:

  • Cardiovascular Science
  • Biophysics
  • Electrophysiology

Background:

  • Conventional cardiac defibrillation uses millisecond shocks.
  • Understanding novel defibrillation methods is crucial for improving patient outcomes.
  • Nanosecond pulse technology offers a potential alternative.

Purpose of the Study:

  • To review the efficacy and safety of cardiac defibrillation using nanosecond shocks.
  • To compare nanosecond shocks with conventional millisecond shocks.
  • To explore the underlying mechanisms and potential risks.

Main Methods:

  • Review of experimental studies on isolated hearts and myocytes.
  • Utilizing optical mapping to assess electrical activity.
  • Measuring energy requirements and cellular damage (electroporation, propidium uptake).

Main Results:

  • Nanosecond shocks defibrillate isolated hearts at lower energies than millisecond shocks.
  • Single nanosecond shocks show minimal damage, but repeated stimulation causes heart deterioration.
  • Nanosecond pulses cause less electroporation in isolated myocytes compared to longer pulses.
  • Distorted calcium gradients observed with repeated nanosecond stimulation.

Conclusions:

  • Nanosecond shocks are a potentially effective defibrillation method with lower energy requirements.
  • The primary mechanism is likely plasma membrane electroporation.
  • Safety concerns exist regarding repeated nanosecond pulse stimulation, necessitating further investigation.