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Updated: Dec 14, 2025

08:42
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
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Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification
Giuseppe Gambino1, Tanja Gambino1, Goran Angelovski1
1MR Neuroimaging Agents, MPI for Biological Cybernetics, Tuebingen, Germany. goran.angelovski@tuebingen.mpg.de.
Abstract:
We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.

