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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Nanoclay-based drug delivery systems and their therapeutic potentials
Nafeesa Khatoon1, Mao Quan Chu, Chun Hui Zhou
1Research Group for Advanced Materials & Sustainable Catalysis (AMSC), State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China. clay@zjut.edu.cn.
Journal of Materials Chemistry. B
|July 21, 2020
Summary
Nanoclays, like montmorillonite and halloysite, offer safe and effective drug delivery systems. These nanomaterials enhance drug loading and controlled release for treating diseases like cancer and infections.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Drug delivery systems face challenges like cytotoxicity and poor drug release.
- Novel nanomaterials are crucial for effective therapeutic strategies against major diseases.
- Clay minerals possess unique properties making them suitable for advanced medical applications.
Purpose of the Study:
- To review recent advancements in nanoclay-based drug delivery systems.
- To explore the applications of nanoclays in gene therapy and tissue engineering.
- To highlight the potential of modified nanoclays for targeted and controlled therapeutic agent release.
Main Methods:
- Review of scientific literature on nanoclay applications in medicine.
- Analysis of clay mineral properties (biocompatibility, surface area, charge).
- Examination of chemical modification strategies for nanoclays (intercalation, surface modification).
Main Results:
- Nanoclays (montmorillonite, kaolinite, halloysite) demonstrate potential as drug carriers.
- Chemical modification enhances nanoclay drug loading via encapsulation, ion exchange, and electrostatic interactions.
- Montmorillonite shows non-toxicity and detoxifying effects; halloysite nanotubes facilitate controlled release of drugs and biomolecules.
Conclusions:
- Nanoclay-based systems offer promising solutions for safe and effective drug delivery.
- Modified nanoclays enable tunable drug loading and controlled release profiles.
- Clay nanoparticles have broad applications in drug/gene delivery, tissue engineering, and bioimaging.
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