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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
Published on: January 11, 2018
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Histologic findings and related diagnostic methods in condylar hyperactivity.
S Espinosa1, E Covarrubias2, R Díaz2
1Oral and Maxillofacial Surgery Department, Hospital Sótero del Río, Santiago, Chile; Oral and Maxillofacial Surgery Service, Clínica Indisa, Santiago, Chile.
International Journal of Oral and Maxillofacial Surgery
|July 22, 2020
Summary
Condylar hyperactivity (CH) diagnosis lacks specific histological markers. Current findings suggest cartilage changes are age-related, not definitive for active CH, necessitating new diagnostic tools.
Area of Science:
- Oral and Maxillofacial Surgery
- Pathology
- Radiology
Background:
- Condylar hyperactivity (CH) is a rare mandibular condition causing progressive deviation and deformation.
- Current diagnostic methods lack consensus, particularly regarding histopathological features.
- Post-condylectomy histopathology cannot reliably confirm or exclude active CH.
Purpose of the Study:
- To review the literature on histopathological findings in condylar hyperactivity.
- To assess the diagnostic value of histology in confirming active CH.
- To identify the need for improved diagnostic tools.
Main Methods:
- Systematic electronic literature search (Medline, Embase, Web of Science, LILACS, grey literature) up to December 2019.
- Inclusion of 17 articles (6 cross-sectional, 11 case series) after screening 660.
- Risk of bias assessment using Newcastle-Ottawa Scale and Institute of Health Economics Quality Appraisal.
Main Results:
- Augmented cartilage layer thickness and subchondral cartilage islands were common (14/17 articles).
- Histological findings appear age-dependent rather than specific to active CH.
- No clear association between SPECT/scintigram uptake and specific histological findings was identified.
Conclusions:
- Histopathological analysis currently lacks specific markers for diagnosing active condylar hyperactivity.
- Observed histological features are likely related to sample age, not disease activity.
- Development of specialized tools for histological evaluation in CH diagnosis is essential.
