Novel Cross-Linked Ocular Bandage Gel Improves Reepithelialization After Photorefractive Keratectomy: A Randomized,...

Area of Science:

• Ophthalmology
• Corneal Surgery
• Wound Healing

Background:

• Photorefractive keratectomy (PRK) creates corneal epithelial defects requiring effective management.
• Standard care for PRK-induced defects involves bandage contact lenses (BCL) and artificial tears.
• Novel therapeutic approaches are sought to optimize corneal healing post-PRK.

Purpose of the Study:

• To compare a new cross-linked hyaluronic acid ocular bandage gel (OBG) with standard BCL and artificial tears.
• To evaluate the safety and effectiveness of OBG in healing PRK-induced epithelial defects.
• To assess the time to complete corneal defect closure and healing rates.

Main Methods:

• A randomized, masked, exploratory study involving 45 myopic patients undergoing bilateral PRK.
• Patients were randomized to receive OBG (different frequencies) or BCL with artificial tears post-PRK.
• Corneal defect size was analyzed using digital slit lamp photos over a 14-day follow-up.

Main Results:

• Higher proportions of patients achieved complete corneal healing by day 3 with OBG (73.3% and 86.7%) compared to control (66.7%).
• Mean wound size was significantly smaller (6%-26%) on day 2 in OBG groups versus control.
• No significant safety concerns or differences in visual function or dryness scores (SPEED) were observed.

Conclusions:

• Cross-linked hyaluronic acid ocular bandage gel (OBG) is a safe and effective option for corneal reepithelialization.
• OBG promotes faster healing of corneal defects compared to standard treatments.
• This gel offers a well-tolerated therapeutic alternative for post-surgical, post-traumatic, or disease-related corneal defects.