Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Interference: Path Lengths

Interference: Path Lengths

Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...

Direct Motor Pathways

Direct Motor Pathways

The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...

Indirect Motor Pathways

Indirect Motor Pathways

The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...

Path Between Thermodynamics States

Path Between Thermodynamics States

Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:

Mean free path and Mean free time

Mean free path and Mean free time

Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."

Streamlines, Streaklines, and Pathlines

Streamlines, Streaklines, and Pathlines

A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

fix pimd/langevin: An efficient implementation of path integral molecular dynamics in LAMMPS.

The Journal of chemical physics·2026

Same author

Enzyme Reset: Water-Mediated Tautomerization Restores the Catalytic Asparagine in Protein <i>O</i>-Fucosyltransferase 1.

Journal of chemical information and modeling·2026

Same author

Ceci n'est pas un committor, yet it samples like one: Efficient sampling via approximated committor functions.

The Journal of chemical physics·2026

Same author

Combining harmonic sampling with the worm algorithm to improve the efficiency of path integral Monte Carlo.

Physical review. E·2026

Same author

Protonation-dependent substrate release in a bacterial homolog of vesicular glutamate.

Biophysical journal·2026

Same author

MiMiCPy-FM: A User-Friendly Force Matching Tool for Extending the Time Scale of QM/MM MD MiMiC Simulations.

Journal of chemical information and modeling·2026

Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026

Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026

Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026

Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026

Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026

Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 14, 2025

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

Metadynamics of Paths.

Davide Mandelli¹, Barak Hirshberg^2,3, Michele Parrinello^1,2,3

¹Atomistic Simulations, Italian Institute of Technology, via Morego 30, 16163 Genova, Italy.

Physical Review Letters

|July 24, 2020

Summary

This summary is machine-generated.

This study introduces a novel molecular dynamics method for exploring chemical reaction pathways. Enhanced sampling techniques allow efficient computation of reaction rates and correlation functions for rare events.

More Related Videos

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

Related Experiment Videos

Last Updated: Dec 14, 2025

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

Area of Science:

Computational chemistry
Molecular dynamics simulations

Background:

Studying rare chemical events requires advanced simulation techniques.
Traditional methods struggle with exploring multiple reaction pathways efficiently.

Purpose of the Study:

To develop a method for sampling reactive pathways using biased molecular dynamics.
To enable unconstrained exploration of multiple reaction routes.
To facilitate computation of kinetic rates and time correlation functions.

Main Methods:

Biased molecular dynamics simulations in trajectory space.
Enhanced sampling techniques.
Reweighted averages along a single trajectory.

Main Results:

Demonstrated unconstrained exploration of multiple reaction routes.
Enabled convenient computation of time correlation functions.
Accessed kinetic rates at no additional cost.
Successfully applied to a model potential and NH3 umbrella inversion in water.

Conclusions:

The proposed algorithm is a powerful tool for studying rare events in molecular systems.
Parallel implementation allows for efficient large-scale simulations.
Offers a cost-effective way to access kinetic information.