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Related Experiment Video

Updated: Dec 14, 2025

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Small Fiber Neuropathy.

David S Saperstein¹

¹Center for Complex Neurology, EDS & POTS, University of Arizona College of Medicine, 1010 East McDowell Road, Suite 101, Phoenix, AZ 85006, USA.

Neurologic Clinics

|July 25, 2020

Summary

This summary is machine-generated.

Small fiber neuropathy diagnosis can be challenging, especially with non-length-dependent symptoms. Skin biopsy for intraepidermal nerve fiber density (IENFD) testing is reasonable in fibromyalgia patients, but clinical context is crucial for accurate interpretation.

Keywords:

Fibromyalgia Intraepidermal nerve fiber density Length-dependent symptoms Small fiber neuropathy

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Published on: February 13, 2018

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

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Published on: April 29, 2013

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

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Published on: June 25, 2019

Area of Science:

Neurology
Dermatology
Pathology

Background:

Small fiber neuropathy (SFN) presents with diverse clinical manifestations.
Length-dependent SFN is typically straightforward to diagnose, unlike non-length-dependent or multifocal presentations.
Accurate diagnosis of SFN is essential for appropriate patient management.

Observation:

Intraepidermal nerve fiber density (IENFD) testing via skin biopsy is a valuable tool for SFN diagnosis.
The utility of IENFD testing in patients with suspected fibromyalgia requires further investigation.
Clinical presentation, history, and physical examination are critical for interpreting IENFD test results.

Findings:

Skin biopsy for IENFD testing is a reasonable approach for patients with apparent fibromyalgia.
IENFD testing should be avoided when neuropathy diagnosis is already evident or not the cause of symptoms.
Pretest probability, alongside clinical assessment, significantly influences the interpretation of IENFD test outcomes.

Implications:

IENFD testing can aid in diagnosing challenging SFN cases, particularly when combined with clinical judgment.
Avoiding inappropriate IENFD testing prevents diagnostic errors and unnecessary procedures.
Integrating clinical data with IENFD results enhances diagnostic accuracy and patient care in small fiber neuropathy.