Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

568
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
568

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breast Cancer, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Oncologic outcomes after poly-4-hydroxybutyrate scaffold in post-mastectomy breast reconstruction: a retrospective, multi-center cohort study.

World journal of surgical oncology·2026
Same author

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
Same author

Age-related differences in psychological distress and persistent postsurgical pain after surgery for management of non-invasive breast lesions.

Breast cancer research and treatment·2026
Same author

Patient Out-of-Pocket Costs and Healthcare Utilization Related to Mastectomy vs Breast Conservation: A Claims-Based Study.

Journal of surgical oncology·2026
Same author

Enabling DCIS subtyping: leveraging foundation models for robust grading and molecular biomarker scoring.

NPJ breast cancer·2026

Related Experiment Video

Updated: Dec 14, 2025

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

594

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Jennifer K Plichta1,2, Yi Ren3, Caitlin E Marks4

  • 1Department of Surgery, Duke University Medical Center, Durham, NC, USA. jennifer.plichta@duke.edu.

Annals of Surgical Oncology
|July 25, 2020
PubMed
Summary

Male breast cancer treatment patterns often mirror female patterns, even when men are excluded from trials. When evidence-based guidelines were applied, men and women showed similar overall survival (OS) outcomes.

Keywords:
Breast radiationBreast surgeryLocal–regional therapyMale breast cancer

More Related Videos

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

3.8K
Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.9K

Related Experiment Videos

Last Updated: Dec 14, 2025

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

594
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

3.8K
Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
06:03

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

6.9K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Clinical Trials

Background:

  • Male breast cancer is rare, and treatment guidelines are primarily based on female data due to trial exclusion.
  • This study examines practice patterns in male and female breast cancer patients post-landmark surgical trials.

Purpose of the Study:

  • To compare breast cancer treatment practices between men and women.
  • To assess the impact of landmark clinical trials on treatment de-escalation in male breast cancer patients.
  • To evaluate survival outcomes in men versus women following the adoption of trial findings.

Main Methods:

  • Analysis of invasive breast cancer cases (2004-2015) from the National Cancer Data Base.
  • Subcohort creation based on eligibility for NSABP-B06, CALGB 9343, and ACOSOG Z0011 trials.
  • Gender-stratified comparison of practice patterns and Cox proportional hazards regression for overall survival (OS).

Main Results:

  • Mastectomy rates remained stable (~80%) for eligible men in the NSABP-B06 cohort; OS was slightly worse (HR 1.19).
  • Men were slower to adopt omission of radiation post-lumpectomy (CALGB 9343 eligible) but had similar OS (HR 0.92).
  • De-escalation of axillary surgery (ACOSOG Z0011) occurred in both genders with comparable OS (HR 0.69 for men).

Conclusions:

  • Adoption of clinical trial results in male breast cancer often parallels that in women, despite men's exclusion from trials.
  • Men and women exhibit similar survival outcomes when study findings are applied to eligible patients.
  • Observational studies are crucial for guiding treatment and improving clinical trial enrollment for male breast cancer patients.