Related Experiment Video

Updated: Dec 13, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.8K

LncRNA SNHG16 functions as an oncogene by sponging miR-200a-3p in pancreatic cancer

J-Q Guo1, Z-J Yang, S Wang

  • 1Department of Emergency, Huaihe Hospital, Henan University, Kaifeng, China.

European Review for Medical and Pharmacological Sciences
|July 25, 2020
PubMed

Insights

This article on long non-coding RNA SNHG16 in pancreatic cancer has been withdrawn due to suspected research misconduct. The publisher retracted the study after authors failed to verify data originality.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play critical roles in cancer development.
  • Specific lncRNAs, like SNHG16, are implicated as potential oncogenes.
  • MicroRNAs (miRNAs) are key regulators of gene expression and can be targeted by lncRNAs.

Purpose of the Study:

  • To investigate the role of lncRNA SNHG16 in pancreatic cancer.
  • To explore the interaction between SNHG16 and miR-200a-3p.
  • To determine if SNHG16 acts as an oncogene in pancreatic cancer.

Main Methods:

  • The study aimed to analyze the expression and function of SNHG16 in pancreatic cancer.
  • Mechanisms involving sponging of miR-200a-3p by SNHG16 were investigated.
  • The oncogenic potential of SNHG16 was assessed in the context of pancreatic cancer.

Main Results:

  • The article suggested that lncRNA SNHG16 functions as an oncogene.
  • SNHG16 was proposed to act by sponging miR-200a-3p.
  • These findings indicated a potential mechanism for pancreatic cancer progression.

Conclusions:

  • The study concluded that SNHG16 promotes pancreatic cancer by sponging miR-200a-3p.
  • This suggests SNHG16 as a potential therapeutic target.
  • However, the article has been withdrawn due to research misconduct allegations.

More Related Videos

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

2.1K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.5K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.7K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.1K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.7K