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Published on: September 26, 2018
[Cardiovascular risk calculators for people living with human immunodeficiency virus]
1Instituto de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Olavarría, Argentina.
Insights
People living with human immunodeficiency virus (HIV) face increased cardiovascular disease risk due to multifactorial causes. This review examines HIV-related cardiovascular epidemiology and risk assessment tools.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- Antiretroviral therapy (ART) has improved life expectancy for people with human immunodeficiency virus (HIV).
- Increased cardiovascular disease (CVD) risk is a significant concern in the HIV population.
- This risk stems from traditional factors, chronic inflammation, and ART's metabolic effects.
Purpose of the Study:
- To review the epidemiology of cardiovascular disease in people living with HIV.
- To discuss the limitations of current cardiovascular risk calculators in this population.
- To guide clinical decision-making for managing CVD risk in HIV.
Main Methods:
- Literature review of epidemiological studies on CVD in HIV.
- Analysis of existing cardiovascular risk assessment tools.
- Discussion of the impact of HIV infection and ART on cardiovascular health.
Main Results:
- CVD is a leading cause of morbidity and mortality in people with HIV.
- Traditional risk calculators may underestimate CVD risk in the HIV population.
- Specific factors related to HIV and its treatment contribute to elevated cardiovascular risk.
Conclusions:
- Managing cardiovascular risk is crucial for improving long-term outcomes in people with HIV.
- Further research is needed to refine risk prediction models for this population.
- A comprehensive approach considering HIV-specific factors is essential for cardiovascular care.
Abstract:
The increasing access and efficacy of antiretroviral therapy has allowed people living with human immunodeficiency virus to achieve a life expectancy similar to that of the general population. However, this goal may be affected by the increased risk of cardiovascular disease in this group. This risk is multifactorial, involving the high prevalence of traditional risk factors, the development of a pro-inflammatory state related to chronic infection, and the use of antiretroviral drugs with an adverse metabolic profile. In daily practice, in order to estimate this risk and guide medical decision-making, different calculators are available. These are based on data from population cohorts, many of them from human immunodeficiency virusnegative subjects. The main aim of this review is to describe the epidemiology of cardiovascular disease in people living with human immunodeficiency virus, the available risk calculators and their use.
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