[Cardiovascular risk calculators for people living with human immunodeficiency virus]

M Grand1, A Diaz2, D Bia3

  • 1Instituto de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Olavarría, Argentina.

Insights

People living with human immunodeficiency virus (HIV) face increased cardiovascular disease risk due to multifactorial causes. This review examines HIV-related cardiovascular epidemiology and risk assessment tools.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Antiretroviral therapy (ART) has improved life expectancy for people with human immunodeficiency virus (HIV).
  • Increased cardiovascular disease (CVD) risk is a significant concern in the HIV population.
  • This risk stems from traditional factors, chronic inflammation, and ART's metabolic effects.

Purpose of the Study:

  • To review the epidemiology of cardiovascular disease in people living with HIV.
  • To discuss the limitations of current cardiovascular risk calculators in this population.
  • To guide clinical decision-making for managing CVD risk in HIV.

Main Methods:

  • Literature review of epidemiological studies on CVD in HIV.
  • Analysis of existing cardiovascular risk assessment tools.
  • Discussion of the impact of HIV infection and ART on cardiovascular health.

Main Results:

  • CVD is a leading cause of morbidity and mortality in people with HIV.
  • Traditional risk calculators may underestimate CVD risk in the HIV population.
  • Specific factors related to HIV and its treatment contribute to elevated cardiovascular risk.

Conclusions:

  • Managing cardiovascular risk is crucial for improving long-term outcomes in people with HIV.
  • Further research is needed to refine risk prediction models for this population.
  • A comprehensive approach considering HIV-specific factors is essential for cardiovascular care.

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
513
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.5K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
708
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
453
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
48.9K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
748