Racial and Ethnic Variation Associated With Human Papillomavirus Genotype in Anal Dysplasia

Area of Science:

• Oncology
• Infectious Diseases
• Epidemiology

Background:

• Human Papillomavirus (HPV) is a known cause of dysplasia and cancer.
• Cervical disease shows HPV genotype prevalence differences across racial/ethnic groups.
• Prevalence of HPV genotypes in anal dysplasia remains understudied.

Purpose of the Study:

• To evaluate the association between HPV genotypes and race/ethnicity in a diverse population with anal dysplasia.
• To identify demographic factors associated with specific HPV genotypes in anal dysplasia.

Main Methods:

• Retrospective review of 517 patients with anal dysplasia (2008-2019).
• HPV genotyping via anal swab (HPV 16, HPV 18, other non-16/18 HR HPV).
• Univariate and multivariate logistic regression analyses were employed.

Main Results:

• Race/ethnicity (P=0.016) and sex (P<0.001) were significantly associated with HPV genotype prevalence.
• Black patients (OR 1.56) and male patients (OR 2.35) were more likely to have non-16/18 HR HPV genotypes.
• 46.8% White, 37.1% Black, 13.2% Hispanic patients identified.

Conclusions:

• Black race and male sex are associated with higher likelihood of non-16/18 HR HPV genotypes in anal dysplasia.
• Many identified HR HPV genotypes are not covered by current vaccines.
• Further research in larger cohorts is needed for HPV vaccination and anal dysplasia screening implications.