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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

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Photoaging Skin Therapy with PRP and ADSC: A Comparative Study.

Luiz Charles-de-Sá¹, Natale Gontijo-de-Amorim², Andrea Sbarbati²

¹Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro-CCS-Bloco C, Avenida Carlos Chagas Filho, 373, Ilha do Fundão, Rio de Janeiro, RJ 21941-902, Brazil.

Stem Cells International

|July 30, 2020

Summary

Platelet-rich plasma (PRP) therapy caused fibrosis in photoaged skin, while adipose-derived stem cells (ADSCs) promoted collagen and elastin regeneration, offering a promising anti-aging effect.

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Area of Science:

Regenerative Medicine
Dermatology
Tissue Engineering

Background:

Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) possess regenerative potential for innovative therapies.
Photoaged skin presents challenges in regenerative treatments.

Purpose of the Study:

To histologically characterize the effects of PRP and ADSC therapies on photoaged skin.
To compare the regenerative outcomes of PRP versus ADSCs in skin aging.

Main Methods:

Prospective randomized study with 20 healthy individuals exhibiting skin aging.
Two treatment protocols: PRP and ADSCs, with biopsies taken pre- and post-treatment (4 months).

Main Results:

PRP treatment induced dermal fibrosis, characterized by increased collagen and linked elastic fibers.
ADSC therapy promoted neoelastogenesis, increasing tropoelastin and fibrillin, and improved solar elastosis.
ADSCs led to increased macrophage polarization and matrix proteinases, suggesting dermal remodeling via elastinolysis.

Conclusions:

PRP therapy resulted in an inflammatory response and increased dermal thickness with a fibrotic appearance.
ADSC therapy demonstrated significant anti-aging effects on photoaged human skin, highlighting its therapeutic promise.