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Updated: Dec 13, 2025
Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
Published on: August 9, 2019
Directed sibling donor cord blood donation in the Chilean Public Health System
Cristián Sotomayor1, Lucía Salas1, José Lattus2
1Unidad de trasplante de Médula Ósea, Hospital Dr. Luís calvo Mackenna, Santiago, Chile.
Insights
Chile's National Childhood Cancer Program (PINDA) collected cord blood units for hematopoietic stem cell transplantation (HSCT). The program enabled HSCT for four high-risk leukemia patients, demonstrating a model for a national cord blood bank.
Area of Science:
- Hematology
- Transplantation Medicine
- Pediatric Oncology
Background:
- Cord blood (CB) is a recognized source for Hematopoietic Stem Cell Transplantation (HSCT).
- Less than 10% of global CB HSCTs utilize matched sibling donors.
- Chile's National Childhood Cancer Program (PINDA) initiated a directed donation program for CB HSCT in 2004.
Purpose of the Study:
- To assess the quantity and characteristics of CB units collected by the PINDA program.
- To evaluate the clinical characteristics and outcomes of patients receiving HSCT from these CB units.
- To analyze the follow-up data of patients undergoing HSCT within the program.
Main Methods:
- An observational, descriptive, and retrospective study design.
- Collection and storage of 60 CB units between January 2004 and October 2018.
- Analysis of patient clinical data and transplantation outcomes.
Main Results:
- 55 CB units were successfully collected and stored, with median volumes and cell counts detailed.
- Four high-risk leukemia patients received HSCT.
- While complications and one death occurred, surviving patients achieved a 100% Karnofsky/Lansky score after an 8-year median follow-up.
Conclusions:
- The PINDA program provided essential HSCT access for four patients lacking other donor options.
- This directed donation initiative serves as a potential model for establishing a public cord blood bank in Chile.
Introduction:
Cord blood (CB) as a source of Hematopoietic Stem Cells for Transplantation (HSCT) is well established. Worldwide, nonetheless, less than 10% of the CB HSCTs are performed with a match sibling donor. Since 2004, the Chilean National Childhood Cancer Program (PINDA) net work, has established a CB directed donation program for HSCT.
Patients And Method:
An obser vational, descriptive and retrospective study was designed to assess the number and characteristics of the CB units collected in the program as well as the number, clinical characteristics and follow-up of the patients who received an HSCT from those CB units between January 2004 and October 2018.
Results:
Sixty CB units have been collected; 55 of them with full records and stored. The median volume collected was 74.8 ml (30.0-170.8), the median number of total nucleated cells was 7.6 x 10e8 (2.0-21.1), and the median of CD34+ cells was 1.6 x 10e6 (0.2-11.6). Four high-risk leukemia patients received HSCT, all of them developed severe complications after transplantation and one patient died due to relapse. Those patients currently alive have a 100% Karnofsky/Lansky score. The median follow-up time was 8 years.
Conclusion:
The PINDA program has allowed 4 patients to be transplan ted who otherwise would not have had access to a donor. This directed donation program could be seen as a model for the development of a public cord blood bank in Chile.
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