Nasal microbiome in chronic rhinosinusitis.

Area of Science:

• Microbiology
• Immunology
• Otorhinolaryngology

Background:

• Chronic rhinosinusitis (CRS) is a persistent inflammatory condition of the nasal passages and sinuses.
• Microbial dysbiosis in the sinus microbiome is implicated in CRS pathogenesis and disease severity.

Approach:

• This review synthesizes current research on the sinus microbiome's role in CRS.
• Literature search conducted on PubMed and Science Direct databases for relevant English articles.
• Analysis of abstracts, references, and titles to identify key studies.

Key Points:

• Endogenous microbiome dysbiosis negatively impacts mucosal health and can worsen CRS.
• Certain bacterial species exert protective or pathogenic effects within the sinus environment.
• Antibiotics can disrupt the nasal microbiome, potentially exacerbating CRS.

Conclusions:

• Probiotics offer a potential therapeutic strategy to restore sinus microbiome balance and immune homeostasis.
• Understanding the sinus-nasal microbiome in health and CRS is crucial for developing novel diagnostics and therapeutics.
• Targeted manipulation of the microbiome via probiotics may lead to significant therapeutic and preventive implications for CRS.