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Related Experiment Video

Updated: Dec 13, 2025

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Collagen-targeted molecular imaging in diffuse liver diseases.

Iris Y Zhou1,2,3, Kenneth K Tanabe4, Bryan C Fuchs5

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.

Abdominal Radiology (New York)
|August 2, 2020
PubMed
Summary

New molecular MRI contrast agents can directly quantify liver fibrosis by targeting collagen. This offers a non-invasive method for assessing disease progression and treatment response in chronic liver diseases.

Keywords:
CollagenECMFibrosisMRIMolecular imaging

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Area of Science:

  • Biomedical Imaging
  • Molecular Imaging
  • Hepatology

Background:

  • Liver fibrosis is a common endpoint for chronic liver diseases (CLD).
  • Liver biopsy is the current gold standard for fibrosis assessment but is invasive.
  • There is a need for non-invasive tools to quantify liver fibrosis.

Purpose of the Study:

  • To develop and validate novel molecular MRI contrast agents for direct collagen quantification.
  • To assess the potential of these agents for staging fibrosis and monitoring treatment response.

Main Methods:

  • Development of novel molecular MRI contrast agents targeting Type I collagen.
  • Validation of these agents in animal models of liver injury.
  • Direct quantification of collagen deposition using molecular MRI.

Main Results:

  • Molecular MRI contrast agents targeting collagen were successfully developed and validated.
  • These agents enable direct quantification of collagen deposition in the liver.
  • The approach showed promise in animal models for assessing fibrosis.

Conclusions:

  • Collagen-targeted molecular imaging probes offer a promising non-invasive method for liver fibrosis assessment.
  • These probes can be used for staging fibrosis progression and monitoring regression in clinical trials.
  • This technology addresses a significant unmet need in the management of chronic liver diseases.