[Particle Design Strategies for Developing Patient Centric Dosage Form Preparations]

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Materials Science

Background:

• Patient-centric drug therapy necessitates advanced dosage form designs.
• Particle design is a key strategy for developing novel drug delivery systems.
• Existing methods require optimization for various administration routes and therapeutic targets.

Purpose of the Study:

• To summarize research on particle design for patient-centric drug therapy.
• To explore the preparation and characterization of functional particles.
• To evaluate polymer-coated liposomes as drug delivery carriers.

Main Methods:

• Preparation and characterization of functional particles using spray drying.
• Development of solid dispersions, solvent deposition particles, and dry emulsion systems.
• Formulation of polymer-coated liposomes, including chitosan-coated liposomes.

Main Results:

• Spray drying yielded functional particles for various dosage forms.
• Chitosan-coated liposomes demonstrated effective oral delivery of peptide drugs (e.g., insulin, calcitonin).
• Polymer-coated liposomes improved drug absorption via inhalation and ocular delivery to the retina.

Conclusions:

• Particle design offers versatile strategies for patient-centric drug delivery.
• Polymer-coated liposomes are effective carriers across multiple administration routes.
• Further research into particle design can significantly advance therapeutic outcomes.