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An overview of signaling pathways regulating YAP/TAZ activity

Boon Chin Heng1,2, Xuehui Zhang3,4, Dominique Aubel5

  • 1Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.

Cellular and Molecular Life Sciences : CMLS
|August 5, 2020
PubMed

Insights

The Hippo pathway effectors, YAP and TAZ, regulate tissue size and have roles in cell proliferation and regeneration. Understanding their signaling pathways offers potential therapeutic applications in regenerative medicine and biomaterials.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Regenerative Medicine

Background:

  • YAP (Yes-associated protein) and TAZ (Transcriptional co-activator with PDZ-binding motif) are homologous proteins.
  • They are key effectors of the Hippo signaling pathway, crucial for maintaining mammalian tissue and organ size.
  • YAP/TAZ also participate in non-Hippo pathways, influencing cell proliferation, regeneration, lineage determination, tumorigenesis, and mechanosensing.

Purpose of the Study:

  • To review microenvironmental cues and signaling pathways regulating YAP/TAZ activation via Hippo and non-Hippo pathways.
  • To summarize YAP/TAZ interactions with TEAD transcription factors and other non-TEAD factors.
  • To provide a perspective on therapeutic applications of YAP/TAZ signaling knowledge.

Main Methods:

  • Literature review of YAP/TAZ signaling pathways.
  • Analysis of YAP/TAZ interactions with transcription factors.
  • Critical perspective on therapeutic potential.

Main Results:

  • YAP/TAZ activation is modulated by diverse microenvironmental cues and signaling networks.
  • YAP/TAZ interact with TEAD1-4 and numerous other transcription factors.
  • Knowledge of YAP/TAZ regulation is expanding.

Conclusions:

  • Understanding YAP/TAZ regulation is crucial for various biological processes.
  • Further insights into YAP/TAZ signaling can drive innovation in biomaterials and tissue engineering.
  • Therapeutic strategies targeting YAP/TAZ hold promise for regenerative medicine and synthetic biology.
Keywords:
HippoMechanismsRegulationSignaling pathwaysTAZYAP

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