[Progress in engineering application of human adenovirus].

Area of Science:

• Virology
• Molecular Biology
• Biotechnology

Background:

• Human adenoviruses are prevalent pathogens responsible for various diseases, including respiratory infections and epidemic keratoconjunctivitis.
• Adenoviruses serve as crucial tools in both experimental research and clinical applications.
• Their utility as virus vectors in gene therapy, particularly in tumor gene therapy and oncolytic virotherapy, is significant and under active investigation.

Purpose of the Study:

• To provide a comprehensive summary of the biological characteristics of adenoviruses.
• To review the epidemiology of human adenovirus infections.
• To outline the current applications of adenoviruses, with a focus on their potential for engineering and future development.

Main Methods:

• Literature review and synthesis of existing research on adenovirus biology.
• Epidemiological data compilation and analysis.
• Survey of current and emerging applications in gene therapy and oncology.

Main Results:

• Adenoviruses possess diverse biological features that enable their use as versatile agents.
• Understanding adenovirus epidemiology is crucial for managing infections and optimizing therapeutic strategies.
• Current applications highlight adenoviruses' potential in gene delivery and cancer treatment.

Conclusions:

• Adenoviruses are significant in human health and biomedical research due to their biological properties and adaptability.
• Further research into adenovirus characteristics and epidemiology will facilitate their enhanced engineering for therapeutic purposes.
• Adenovirus-based strategies hold considerable promise for advancing gene therapy and oncolytic virotherapy.