Related Experiment Videos
Experimental and clinical double lung transplantation
G A Patterson1, J D Cooper, J H Dark
1Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada.
The Journal of Thoracic and Cardiovascular Surgery
|January 1, 1988
Summary
En bloc double lung transplantation was technically feasible in animal models, leading to successful clinical application. This innovative surgical technique offers excellent lung function and tracheal healing for patients with severe emphysema.
Area of Science:
- Thoracic Surgery
- Transplantation Immunology
- Pulmonary Medicine
Background:
- En bloc double lung transplantation is a complex surgical procedure.
- Previous studies demonstrated technical feasibility in canine models.
- The current study aimed to assess survival and efficacy in non-human primates.
Observation:
- Survival experiments were conducted in cynomolgus monkeys using profound hypothermia and circulatory arrest.
- Cardiopulmonary bypass was avoided due to the small size of the animals.
- Despite complexities, experiments confirmed excellent lung function and tracheal healing.
Findings:
- Few long-term survivals were achieved in monkey experiments due to procedural complexities.
- The technique demonstrated excellent lung function and satisfactory tracheal healing in surviving animals.
- The first clinical en bloc double lung transplantation was successfully performed on a patient with alpha 2-antitrypsin deficiency-related emphysema.
Implications:
- Successful clinical application of en bloc double lung transplantation in a patient with end-stage emphysema.
- The patient regained normal activities with excellent lung function post-transplantation.
- This approach holds promise for treating severe lung diseases like emphysema.