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Ascorbic Acid Promotes KIR Demethylation during Early NK Cell Differentiation.

Cheng-Ying Wu1, Bin Zhang1, Hansol Kim1

  • 1Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and.

Journal of Immunology (Baltimore, Md. : 1950)
|August 8, 2020
PubMed
Summary

Variegated killer Ig-like receptor (KIR) expression in NK cells is regulated by DNA demethylation. Ascorbic acid treatment in vitro induces KIR promoter demethylation and expression in immature NK cells.

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