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Topical phenytoin effects on palatal wound healing
Anuja Doshi1,2, James W McAuley3, Dimitris N Tatakis1
1Division of Periodontology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Journal of Periodontology
|August 8, 2020
Summary
Topical phenytoin (PHT) applied to palatal wounds reduced pain and swelling, potentially improving healing outcomes. This study investigated PHT
Area of Science:
- Oral surgery
- Wound healing research
- Pharmacology
Background:
- Autogenous soft tissue grafts for palatal defects have donor site morbidity.
- Topical phenytoin (PHT) is explored as an alternative treatment for palatal wounds.
Purpose of the Study:
- To assess clinical, histological, and patient outcomes of topical phenytoin treatment on experimental palatal wounds.
- To compare phenytoin treatment against a control in a split-mouth clinical trial.
Main Methods:
- A prospective split-mouth study involved creating standardized palatal wounds in systemically healthy adults.
- One wound side received 10% phenytoin (PHT) USP, the other received a carrier control.
- Clinical healing, histology, and patient-reported pain and swelling were evaluated over 21 days.
Main Results:
- Phenytoin treatment significantly reduced pain and swelling compared to the control group.
- PHT application positively influenced granulation tissue appearance over time.
- No significant histological differences were observed between phenytoin and control groups.
Conclusions:
- Topical phenytoin (PHT) application may enhance palatal wound healing.
- PHT demonstrates potential as a beneficial treatment for palatal wound management.
- Further research is warranted to confirm these findings.
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