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Updated: Dec 12, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Post-Traumatic Stress Disorder and Severe Maternal Morbidity
Maria J Small1, Kaboni W Gondwe2, Haywood L Brown3
1Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA; Division of Maternal Fetal Medicine, Duke University School of Medicine, Duke University Medical Center, Box 3967, Durham, NC 27710, USA.
Post-traumatic stress disorder (PTSD) can follow pregnancy complications like miscarriage or preterm birth, especially after life-threatening events. Early screening and treatment are crucial for maternal and child well-being and reducing health disparities.
Area of Science:
- Reproductive health
- Maternal mental health
- Perinatal mental health
Background:
- Post-traumatic stress disorder (PTSD) is linked to adverse pregnancy outcomes including miscarriage, intrauterine fetal demise, and preterm birth.
- Severe maternal morbidity and near-miss events, disproportionately affecting minority and rural populations, are increasingly associated with PTSD.
- Various pre-existing conditions and events during labor and delivery elevate the risk for developing PTSD.
Purpose of the Study:
- To examine the association between pregnancy complications and PTSD.
- To highlight the heightened risk of PTSD in women experiencing severe maternal morbidity or near-miss events.
- To emphasize the importance of postpartum evaluation for PTSD screening.
Main Methods:
- This study synthesizes existing research on PTSD following pregnancy complications.
- It reviews data linking severe maternal morbidity and near-miss events to PTSD.
- The analysis considers risk factors contributing to perinatal PTSD.
Main Results:
- PTSD frequently accompanies miscarriage, intrauterine fetal demise, and preterm birth.
- Women facing life-threatening labor and delivery events report higher PTSD levels.
- Severe maternal morbidity and near-miss events show a significant association with PTSD, particularly in vulnerable populations.
Conclusions:
- Postpartum evaluation is a critical opportunity for screening and addressing PTSD.
- Untreated perinatal PTSD negatively affects maternal and child health long-term.
- Addressing perinatal PTSD is essential for mitigating health disparities.
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