A Multifunctional Microfluidic Platform for High-Throughput Experimentation of Electroorganic Chemistry

Area of Science:

• Electroorganic synthesis
• Sustainable chemistry
• Microfluidics

Background:

• Electroorganic synthesis offers sustainable transformations but faces challenges in reaction condition screening due to complex setups.
• Efficient screening is crucial for discovering new reactivities in electroorganic chemistry.

Purpose of the Study:

• To develop a microfluidic platform for automated high-throughput experimentation (HTE) in electroorganic synthesis.
• To enable rapid screening of reaction conditions and kinetic measurements at a microliter scale.

Main Methods:

• A microfluidic platform with micro-fabricated interdigitated electrodes for reaction condition screening.
• Microliter-scale cyclic voltammetry for measuring kinetics of mediated anodic oxidations.

Main Results:

• Demonstrated rapid electrochemical reaction condition screening for a radical-radical cross-coupling reaction.
• Successfully measured kinetics for mediated anodic oxidations using the developed platform.

Conclusions:

• The microfluidic platform enables automated HTE for electroorganic synthesis at a 15-microliter scale.
• This modular approach facilitates efficient screening and kinetic studies, applicable to diverse electroorganic chemistry applications.