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Updates in Appendix Pathology: The Precarious Cutting Edge

Norman J Carr1

  • 1Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Aldermaston Road, Basingstoke RG24 9NA, UK.

Surgical Pathology Clinics
|August 11, 2020
PubMed

Insights

Accurate diagnosis of appendiceal tumors, including mucinous and nonmucinous adenocarcinomas, is crucial. New classifications aid consistent nomenclature for better patient management and research comparison.

Area of Science:

  • Gastroenterology
  • Pathology
  • Oncology

Background:

  • Appendiceal tumors encompass a spectrum from benign to malignant, including mucinous and nonmucinous adenocarcinomas.
  • Accurate classification and nomenclature are essential for effective patient management and comparative research.
  • Distinguishing between various appendiceal neoplasms, such as serrated polyps and low-grade appendiceal mucinous neoplasm, is clinically important.

Purpose of the Study:

  • To highlight the importance of accurate diagnosis and nomenclature for appendiceal neoplasms.
  • To discuss the classification of mucinous appendiceal tumors and their distinction from other appendiceal lesions.
  • To emphasize the role of recent consensus guidelines and WHO classification in standardizing terminology.

Main Methods:

  • Review of current literature and classification systems for appendiceal neoplasms.
  • Analysis of diagnostic criteria for differentiating various types of appendiceal tumors.
  • Emphasis on the impact of updated nomenclature on clinical practice and research.

Main Results:

  • Mucinous appendiceal tumors include low-grade and high-grade appendiceal mucinous neoplasm and mucinous adenocarcinoma.
  • Nonmucinous adenocarcinomas are less common.
  • Serrated polyps and low-grade appendiceal mucinous neoplasm require careful differentiation, alongside recognition of goblet cell adenocarcinomas.

Conclusions:

  • Adoption of recent consensus guidelines and WHO classification promotes consistent nomenclature for appendiceal neoplasms.
  • Accurate diagnosis is vital for patient management and facilitates inter-center data comparison.
  • Standardized terminology improves the reliability of tumor registries and research outcomes.
Keywords:
Appendiceal neoplasiaAppendixGoblet cell adenocarcinomaGoblet cell carcinoidMucinous neoplasiaPseudomyxoma peritonei

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