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Non-inferiority clinical trials: importance and applications in health sciences

Heitor Marques HonÓrio1, Linda Wang2, Daniela Rios1

  • 1Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, Universidade de São Paulo, Bauru, SP, Brazil.

Brazilian Oral Research
|August 14, 2020
PubMed

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Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
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