Surgical treatment for heart failure: cell-based therapy with engineered tissue
Jordan J Lancaster1,2, Jen Watson Koevary1,3, Ikeotunye Royal Chinyere1,2
1Sarver Heart Center, University of Arizona, Tucson, AZ 85724, United States.
Vessel Plus
|August 14, 2020
Summary
This review explores cell-based therapies for heart failure, emphasizing tissue engineering for cell delivery to damaged hearts. It covers stem cell approaches, mechanisms, and safety, highlighting future research needs.
Area of Science:
- Cardiovascular Medicine
- Regenerative Medicine
- Biotechnology
Background:
- Heart failure remains a leading cause of morbidity and mortality worldwide.
- Current treatments offer limited efficacy in restoring cardiac function.
- Cell-based therapy presents a promising regenerative approach for cardiac repair.
Purpose of the Study:
- To review cell-based therapy strategies for heart failure.
- To focus on tissue engineering for effective cell delivery to the myocardium.
- To provide an overview of current progress and future directions in the field.
Main Methods:
- Review of current literature on cell-based therapies for heart failure.
- Focus on pluripotent stem cell-derived cells and their applications.
- Discussion of tissue engineering techniques for cardiac cell delivery.
Main Results:
- Pluripotent stem cell-derived cells show potential for cardiac regeneration.
- Tissue engineering strategies are crucial for successful cell engraftment and function.
- Autologous and allogeneic approaches, immunologic modulation, and safety are key considerations.
Conclusions:
- Cell-based therapy, particularly with stem cells and advanced delivery systems, holds significant promise for treating heart failure.
- Further research is needed to optimize cell sources, delivery methods, and long-term safety and efficacy.
- Translational challenges must be addressed to advance this therapy from bench to bedside.
