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Multicenter randomized controlled trial of exercise in aortic dissection survivors: rationale, design, and initial
Yasmin A Toy1, Kayla N House1, Leslie M Boyer2
1Department of Internal Medicine, John P. and Kathrine G. McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Vessel Plus
|March 4, 2026
Summary
A guided exercise program is safe for survivors of thoracic aortic dissection (TAD). This finding offers hope for improved physical activity recommendations and quality of life for TAD patients.
Area of Science:
- Cardiovascular Research
- Exercise Physiology
- Rehabilitation Medicine
Background:
- Lack of evidence-based guidelines for exercise post-thoracic aortic dissection (TAD).
- Variable recommendations often lead to physical activity restriction in TAD survivors.
- Need for safety and efficacy data on structured exercise interventions for TAD recovery.
Purpose of the Study:
- To evaluate the safety and efficacy of a moderate-intensity guided exercise program for thoracic aortic dissection survivors.
- To establish evidence-based recommendations for physical activity in TAD recovery.
- To assess the impact of guided exercise on psychological well-being and physical function.
Main Methods:
- Multicenter randomized controlled trial involving TAD survivors (Type A or B, ≥90 days post-dissection).
- Guided exercise circuit included aerobic, isotonic, and isometric exercises with home continuation and virtual follow-up.
- Primary endpoint: Change in PROMIS-29 T-score (anxiety/depression); Secondary endpoints: grip strength, weight, blood pressure, arterial biomechanics.
Main Results:
- Preliminary analysis of 81 participants showed the guided exercise circuit was safely completed.
- No severe hypertension, injury, or adverse cardiovascular events were associated with the program.
- Prevalent adverse arterial waveform or ambulatory blood pressure monitoring characteristics at enrollment were linked to exertional hypertension.
Conclusions:
- Guided exercise is a safe intervention for thoracic aortic dissection survivors.
- Further follow-up will conclude in October 2024 to finalize efficacy data.
- Findings support the development of evidence-based exercise guidelines for TAD recovery.
