Related Experiment Videos
The CD11/CD18 leukocyte glycoprotein deficiency.
1Division of Hematology/Oncology, University of Michigan School of Medicine, Ann Arbor.
Hematology/Oncology Clinics of North America
|March 1, 1988
Summary
CD11/CD18 leukocyte glycoprotein deficiency is a rare inherited disorder causing severe bacterial infections due to impaired leukocyte function. This condition results from a deficiency in CD11/CD18 glycoprotein expression on leukocyte membranes.
Area of Science:
- Immunology
- Genetics
- Hematology
Background:
- CD11/CD18 leukocyte glycoprotein deficiency is a rare inherited disorder.
- It is characterized by recurrent, severe bacterial infections.
- The molecular basis involves impaired leukocyte function.
Purpose of the Study:
- To elucidate the underlying molecular defect in CD11/CD18 leukocyte glycoprotein deficiency.
- To understand the impact of this deficiency on leukocyte function and host defense.
Main Methods:
- Analysis of leukocyte membrane glycoproteins.
- Assessment of leukocyte adhesion and function.
- Genetic analysis to identify mutations.
Main Results:
- Demonstrated a deficiency in the expression of CD11/CD18 glycoproteins on leukocyte surfaces.
- Correlated this deficiency with impaired leukocyte adhesion and migration.
- Identified the molecular basis of the disease.
Conclusions:
- CD11/CD18 leukocyte glycoprotein deficiency is caused by a lack of essential leukocyte membrane glycoproteins.
- This deficiency severely compromises the immune system, leading to recurrent infections.