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The Atopy Index Inventory: A Brief and Simple Tool to Identify Atopic Patients.

Federica Di Berardino1, Diego Zanetti2, Daniele Monzani3

  • 1Audiology Unit, Department of Specialist Surgical Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, DISCCO (Department of Clinical Sciences and Community Health), University of Milan, Milan, Italy, federica.diberardino@unimi.it.

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
|August 14, 2020
PubMed
Summary

A new questionnaire, the Atopy Index Inventory (AII), accurately identifies atopy in ear, nose, and throat patients. This simple tool aids in early detection and management of allergic conditions.

Keywords:
AllergyAtopyEar, nose, and throat diseasesImmunoglobulin EIndexInventoryOtolaryngological outpatientsQuestionnaireRhinitis

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Area of Science:

  • Allergy and Immunology
  • Otolaryngology
  • Clinical Diagnostics

Background:

  • Atopy and ear, nose, and throat (ENT) diseases are frequently associated.
  • No clinical tool currently exists to identify atopic patients within ENT settings.
  • Early identification of atopy is crucial for appropriate immunoallergological evaluation.

Purpose of the Study:

  • To develop and validate a questionnaire for predicting atopy in adult patients.
  • To create a simple, accurate screening tool for ENT patients.
  • To aid in the clinical management of atopic individuals.

Main Methods:

  • Developed and administered the 11-item Atopy Index Inventory (AII) to 226 adult subjects.
  • Validated atopic status using immunoallergological evaluation per EAACI guidelines.
  • Assessed internal consistency and clinical validity of the AII.

Main Results:

  • The AII demonstrated high accuracy with sensitivity of 0.97 and specificity of 0.91.
  • Logistic regression identified key "decisive" and "probability" items for atopy prediction.
  • The tool showed significant differences between atopic and healthy groups (p < 0.0001) and strong ROC curve performance (AUC = 0.94).

Conclusions:

  • The Atopy Index Inventory (AII) is a brief, simple, and accurate tool for screening atopic individuals in ENT practice.
  • The AII facilitates timely clinical management of patients with potential allergic conditions.
  • This validated questionnaire supports improved patient care pathways for atopy.