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Trace elements and oxidative stress status in patients with psoriasis
Adnan Kirmit1, Saadet Kader2, Mustafa Aksoy3
1Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
Postepy Dermatologii I Alergologii
|August 15, 2020
Summary
Psoriasis patients show altered levels of trace elements and oxidative stress markers. Specifically, copper and C-reactive protein were elevated, while selenium and zinc were decreased, indicating a changed oxidant-antioxidant balance.
Area of Science:
- Dermatology
- Biochemistry
- Clinical Medicine
Background:
- Psoriasis is a prevalent inflammatory skin condition with unclear etiopathogenesis.
- Trace elements and oxidative stress are implicated in the development of psoriasis.
Purpose of the Study:
- To investigate serum trace element concentrations and oxidative stress markers in psoriasis patients.
- To compare these levels between patients with psoriasis and healthy individuals.
Main Methods:
- Serum levels of sodium, potassium, calcium, phosphorus, magnesium, iron, selenium, zinc, and copper were measured.
- Oxidative stress markers including ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO), and ferroxidase (FOX) activity were assessed.
- C-reactive protein (CRP) was analyzed as an inflammatory marker in 87 psoriasis patients and 60 healthy controls.
Main Results:
- Psoriasis patients exhibited significantly higher levels of IMA, IMA/Albumin, CAT, copper (Cu), FOX, and CRP compared to controls.
- Serum levels of selenium (Se), zinc (Zn), and albumin were significantly lower in psoriasis patients.
- No significant differences were observed in sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), and MPO levels between the groups.
Conclusions:
- The study indicates altered trace element profiles and a disturbed oxidant-antioxidant balance in patients with psoriasis.
- These findings suggest a potential role for trace elements and oxidative stress in the pathophysiology of psoriasis.
