Related Experiment Video
Updated: Dec 12, 2025
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
14.8K
A Giant Childhood Mesenteric Lipoblastoma With Extensive Maturation
Anthony I Squillaro1, Monica D Chow1, Fernando Arias1
1Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Frontiers in Pediatrics
|August 15, 2020
Summary
This case study highlights a rare, large mesenteric lipoblastoma in a child, emphasizing its potential for late diagnosis. Surgical resection was successful, with histology confirming mature adipocytes and cytogenetics revealing a characteristic translocation.
Area of Science:
- Pediatric Surgery
- Pediatric Oncology
- Soft Tissue Tumors
Background:
- Abdominal lipoblastomas are rare pediatric soft tissue tumors.
- Mesenteric origin is exceptionally uncommon, often leading to delayed diagnosis due to slow growth and intra-abdominal location.
Observation:
- A 12-year-old male presented with chronic abdominal distension and new-onset early satiety.
- Imaging revealed a large intra-abdominal mass; surgical exploration identified a 33 x 27 x 15 cm mesenteric mass encasing small intestine.
Findings:
- Complete surgical resection of the large mesenteric mass was achieved.
- Histology showed mature adipocytes, consistent with lipoma-like changes.
- Cytogenetic analysis detected a t(2;8)(q24.3;q13) translocation, a known marker for lipoblastomas.
Implications:
- This case represents one of the largest documented mesenteric lipoblastomas with mature histology.
- Highlights the importance of considering lipoblastoma in pediatric abdominal masses, even with atypical presentations.
- Successful resection and identification of genetic markers aid in understanding tumor behavior and prognosis.
