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Updated: Dec 12, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides
Yulong Zhong1, Brice Kauffmann2, Wenwu Xu3
1Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, New York 14260, United States.
Abstract:
Aromatic oligoamides adopting helical conformations are synthesized by coupling carboxyl-terminated basic units having two, four, and eight residues to amine-terminated oligomer precursors. Coupling yields show no noticeable reduction with the size of the basic units or the final product. One- and two-dimensional NMR spectroscopy and computational studies demonstrate the reliable helical folding of these oligomers. The X-ray structure of 16mer 7 reveals a compact, multiturn helix having a 9 Å inner pore.
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