Related Experiment Video
Updated: Dec 12, 2025

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
Gray matter volume abnormalities and clinical correlates in OCD with exclusive washing dimension
Prabhath Gujjadi Kodancha1, Venkataram Shivakumar2, Dania Jose2
1North Western Mental Health, Melbourne Health, Psychiatry, Melbourne, VIC, Australia.
Objective:
Obsessive compulsive disorder (OCD) is increasingly being recognized as a heterogeneous disorder with various symptom dimensions. In order to understand the neurobiology of obsessive-compulsive disorder (OCD), it is important to understand the brain basis of homogeneous symptom groups. In this study we investigated the gray matter (GM) changes and correlates of an exclusively homogenous sample of OCD patients (washers with no other obsessive compulsive symptoms).
Method:
We compared the structural MRI scans (3T) using voxel-based morphometry (VBM) of washers (N = 35) with matched healthy controls (HC) (N = 39).
Results:
We found volume deficits corresponding to right inferior frontal gyrus, parahippocampal gyrus and right anterior lobe of cerebellum among washers compared to HC. Among the washers, GM volume of right inferior frontal gyrus, right uncus of the limbic lobe, left cuneus and left superior temporal lobe had significant negative correlation with the illness severity score.
Conclusion:
Examining homogenous sub-groups of OCD patients may help us further our understanding of neurobiology of OCD.
More Related Videos
Related Concept Videos
Obsessive-Compulsive Disorder
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Oppositional Defiant Disorder
Diagnostic Criteria and...
Bulimia Nervosa
Generalized Anxiety Disorder
Diagnostic and Statistical Manual of Mental Disorders (DSM)

