Related Experiment Video
Updated: Dec 11, 2025

Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
Published on: October 25, 2024
Reinventing Molecular Imaging with Total-Body PET, Part I: Technical Revolution in Evolution
Babak Saboury1, Michael A Morris2, Faraz Farhadi3
1Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA; Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore, MD, USA; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Abstract:
Total-body PET (TB-PET) is a technical advancement providing improved signal detection (effective sensitivity). This is achieved through a novel extended detector geometry among many other fine attunements. This technical evolution will ripple through molecular imaging revolutionizing clinical practice beyond the expectations of its designers. This article explores how this leap forward in effective sensitivity through TB-PET could enable dose reduction, faster imaging, temporal resolution improvement, dynamic imaging, and the in vivo noninvasive study of clinical systems biology. TB-PET has the potential to be an enabler of disruptive innovations in molecular imaging. This will change the landscape of medical imaging.
Related Concept Videos
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET

