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Updated: Dec 11, 2025

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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[Protein kinase inhibitors can induce retinopathy]

Johanne Bjerre Lindboe1, Hassan Javed Ahmed, Christos Eleftherios Christakopoulos

  • 1blindboe@hotmail.com.

Ugeskrift for Laeger
|August 18, 2020
PubMed

Insights

Targeted cancer therapies, like MEK/BRAF inhibitors, can cause reversible neuroretinal detachments. This case report highlights the importance of eye exams for patients undergoing such treatments.

Area of Science:

  • Oncology
  • Ophthalmology

Background:

  • Targeted therapies, including mitogen-activated protein-kinase-kinase/B-Raf proto-oncogene (MEK/BRAF) inhibitors, have improved outcomes for metastatic melanoma patients.
  • These novel treatments are increasingly utilized in oncological practice.

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