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Updated: Dec 11, 2025
Highly-Multiplexed Tissue Imaging with Raman Dyes
Published on: April 21, 2022
Photoinduced Enhanced Raman Probe for Use in Highly Specific and Sensitive Imaging for Tyrosine Dimerization in
Zi-Yu Ke1, Chi-Jui Tsai1, Pei-Hsuan Liao1
1Department of Chemistry, National Taiwan University, Taipei, Taiwan 10617.
Abstract:
A background-free photoinduced enhanced Raman (PIER) probe for highly sensitive detection of tyrosine dimerization process due to oxidative reaction in inflammatory cells is presented. The PIER probe could monitor oxidative reaction in real time by producing time-resolved spectral with discrete changes in Raman intensity. To the best of our knowledge, this is the first report on C≡C probes with PIER and vastly improved Raman activity. These results will contribute to the cutting edge of development of stable and highly sensitive chemical imaging technology.
