Related Experiment Video

Updated: Dec 11, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development

Yang Xun1, Hua Yang1, Jiekai Li1

  • 1Department of Basic Medicine and Biomedical Engineering, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong Province, China.

Reviews of Physiology, Biochemistry and Pharmacology
|August 21, 2020
PubMed

Insights

Chemokine receptors are often overexpressed in tumors, driving cancer growth and spread. Targeting these receptors with antagonists offers a promising new strategy for anti-tumor therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Chemokine receptors, part of the G protein-coupled receptor superfamily, are frequently overexpressed in malignant tumors.
  • Their activation by ligands triggers signaling pathways that promote tumor growth and metastasis, leading to poor clinical outcomes.

Purpose of the Study:

  • To review recent studies on the expression and function of CXC chemokine receptors in tumor microenvironments.
  • To discuss recent advancements in cancer therapy utilizing CXC chemokine receptor antagonists.

Main Methods:

  • Literature review of recent studies.
  • Analysis of research on CXC chemokine receptor expression and function in various cancers.
  • Examination of therapeutic strategies involving CXC chemokine receptor antagonists.

Main Results:

  • CXC chemokine receptors play a significant role in the tumor microenvironment.
  • Overexpression of these receptors is linked to tumor progression and metastasis.
  • CXC chemokine receptor antagonists show potential as anti-cancer agents.

Conclusions:

  • CXC chemokine receptors are critical regulators of tumor progression and metastasis.
  • Targeting CXC chemokine receptors represents a promising therapeutic avenue for cancer treatment.
  • Further research into CXC chemokine receptor antagonists is warranted for clinical application.
Keywords:
CXC antagonistsCXC chemokine receptorsTumor microenvironment

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