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Updated: Dec 11, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
Published on: March 18, 2014
Oxygen vacancy-enhanced photothermal performance and reactive oxygen species generation for synergistic tumour
Chengjia Peng1, Jingju Liu, Liping Guo
1Key Laboratory of Polyoxometalate Science of Ministry of Education, National & Local United Engineering Laboratory for Power Batteries, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun, Jilin Province 130024, P. R. China. zhoum739@nenu.edu.cn.
Abstract:
Vacancy engineering is a robust strategy to tune nanomaterials' electronic structures for physicochemical properties regulation. Here, we report and realize the first oxygen vacancy-enhanced photothermal and oxidation dual-induced synergistic tumour therapy using oxygen vacancies enriched MnO2@Au nanoconstructs as the therapeutic agent with a high photothermal effect, enhanced highly-toxic superoxide radical generation, good biocompatibility and tumour microenvironment regulation capacity. Our work opens up a new route for cancer nanotheranostics by regulating the electronic structure of nanomaterials resulting in enhanced efficacy.
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