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Related Experiment Video

Updated: Dec 11, 2025

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study.

Antonio Scarano¹, Francesco Carinci², Tiziana Orsini³

¹Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini, 31 66100 Chieti, Italy.

Materials (Basel, Switzerland)

|August 23, 2020

Summary

Titanium implants with a silver-titanium dioxide nanoparticle coating show no adverse effects on bone density or bone-implant contact. This novel coating supports osseointegration, suggesting potential for clinical use in dental implants.

Keywords:

anatase antimicrobic activity bifunctional molecule dental implants implant surface osseointegration

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Last Updated: Dec 11, 2025

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Area of Science:

Biomaterials Science
Nanotechnology
Orthopedic Research

Background:

Titanium implants require surface treatments to enhance biocompatibility and reduce peri-implantitis.
Nanofabrication techniques offer potential for implant surfaces that inhibit bacterial colonization and improve osteointegration.
Peri-implantitis and mucositis are common clinical challenges impacting implant longevity.

Purpose of the Study:

To evaluate the bone response to titanium implants coated with a bifunctional molecule.
To assess the antimicrobial activity and osteointegration of silver ions covalently bound to titanium dioxide nanoparticles on implant surfaces.

Main Methods:

36 implants were placed in 18 rabbits, with two groups: Control (acid-etched and sandblasted) and Test (surface-treated and coated with silver-bound TiO2 nanoparticles).
Bone density and bone-implant contact percentage were measured at two, four, and eight weeks post-implantation.

Main Results:

No statistically significant differences in bone density were observed between Control and Test implants at any time point (p > 0.05).
No statistically significant differences in bone-implant contact percentage were found between groups at any experimental time point (p > 0.05).
The silver-coated implants demonstrated no adverse effects on osseointegration in the rabbit model.

Conclusions:

Titanium implants coated with silver-bound titanium dioxide nanoparticles exhibit excellent bone integration.
The silver coating did not adversely affect bone tissue healing or osseointegration in a rabbit model.
These findings suggest promising clinical applications for silver-functionalized titanium implants.