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Melkersson-Rosenthal Syndrome Induced by COVID-19

Bahadır Taşlıdere1, Liljana Mehmetaj1, Ayşe Büşra Özcan1

  • 1Department of Emergency Medicine, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey.

The American Journal of Emergency Medicine
|August 25, 2020
PubMed

Insights

Melkersson-Rosenthal syndrome, a rare condition, may be linked to COVID-19. This association is suggested by mast cell involvement observed in both conditions, highlighting a potential new factor in the syndrome's etiology.

Area of Science:

  • Neurology
  • Immunology
  • Dermatology

Background:

  • Melkersson-Rosenthal syndrome is a rare neurological disorder characterized by orofacial edema, facial paralysis, and fissured tongue.
  • Mast cells are implicated in the inflammatory processes of Melkersson-Rosenthal syndrome.
  • Mast cell activation is also a known factor in the pathogenesis of COVID-19.

Observation:

  • A case study of a female patient presenting with symptoms consistent with Melkersson-Rosenthal syndrome is detailed.
  • The patient exhibited edema in the right lower lip, right facial paralysis, and a fissured tongue.
  • This presentation occurred in the context of COVID-19.

Findings:

  • The study highlights the potential role of mast cells in linking Melkersson-Rosenthal syndrome and COVID-19.
  • Activated mast cells release cytokines, contributing to inflammation in both conditions.
  • This suggests a possible novel association between the viral infection and the syndrome.

Implications:

  • The findings suggest that COVID-19 may be an associated factor in the etiology of Melkersson-Rosenthal syndrome.
  • This expands the understanding of potential triggers for this rare condition.
  • Further research is warranted to explore this connection and its clinical significance.
Keywords:
COVID-19Fissured tongueMast cellsOrofacial edema

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