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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Complete dimensional collapse in the continuum limit of a delayed SEIQR network model with separable distributed
C P Vyasarayani1, Anindya Chatterjee2
1Mechanical and Aerospace Engineering, Indian Institute of Technology Hyderabad, Sangareddy, 502285 India.
Abstract:
We take up a recently proposed compartmental SEIQR model with delays, ignore loss of immunity in the context of a fast pandemic, extend the model to a network structured on infectivity and consider the continuum limit of the same with a simple separable interaction model for the infectivities . Numerical simulations show that the evolving dynamics of the network is effectively captured by a single scalar function of time, regardless of the distribution of in the population. The continuum limit of the network model allows a simple derivation of the simpler model, which is a single scalar delay differential equation (DDE), wherein the variation in appears through an integral closely related to the moment generating function of . If the first few moments of u exist, the governing DDE can be expanded in a series that shows a direct correspondence with the original compartmental DDE with a single . Even otherwise, the new scalar DDE can be solved using either numerical integration over u at each time step, or with the analytical integral if available in some useful form. Our work provides a new academic example of complete dimensional collapse, ties up an underlying continuum model for a pandemic with a simpler-seeming compartmental model and will hopefully lead to new analysis of continuum models for epidemics.
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