Related Experiment Video
Updated: Dec 11, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Remdesivir and its antiviral activity against COVID-19: A systematic review
Andri Frediansyah1,2, Firzan Nainu3, Kuldeep Dhama4
1Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia.
Background:
The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.
Methods:
Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.
Results:
Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.
Conclusion:
Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.
Related Concept Videos
Subviral Agents
Antimicrobial Effectiveness
Retroviruses
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Therapeutic Drug Monitoring: Overview and Classification
Retrovirus Life Cycles

