Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.7K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying Intracellular Nanoparticle Distributions with Three-Dimensional Super-Resolution Microscopy.

ACS nano·2023
Same author

Bioimaging with Upconversion Nanoparticles.

Advanced photonics research·2023
Same author

Controlling Nanoparticle Uptake in Innate Immune Cells with Heparosan Polysaccharides.

Nano letters·2022
Same author

Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake.

Nano letters·2022
Same author

Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds.

Antiviral research·2019
Same author

Disruption of the transcription factor recombination signal-binding protein-Jkappa (RBP-J) leads to veno-occlusive disease and interfered liver regeneration in mice.

Hepatology (Baltimore, Md.)·2008
Same journal

Navigating the Computational Landscape for Drug Repurposing.

Annual review of pharmacology and toxicology·2026
Same journal

Microplastics and Atherosclerosis: Mechanisms.

Annual review of pharmacology and toxicology·2026
Same journal

Treating Pregnant and Lactating Women: Insights from Clinical Pharmacology.

Annual review of pharmacology and toxicology·2026
Same journal

<i>Caenorhabditis elegans</i> as a Model System for Environmental Mitotoxicants.

Annual review of pharmacology and toxicology·2025
Same journal

Introduction to the Theme "New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology".

Annual review of pharmacology and toxicology·2025
Same journal

A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of <i>Staphylococcus aureus</i>.

Annual review of pharmacology and toxicology·2025
See all related articles

Related Experiment Video

Updated: Dec 11, 2025

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
07:08

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

7.8K

Nanoparticle Toxicology.

Wen Yang1, Lin Wang1, Evan M Mettenbrink1

  • 1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma 73019, USA;

Annual Review of Pharmacology and Toxicology
|August 26, 2020
PubMed
Summary
This summary is machine-generated.

Human exposure to nanoparticles is unavoidable. This review explores nanoparticle toxicity mechanisms and proposes strategies for safe nanotechnology applications.

Keywords:
ROSanti-PEG antibodynanoparticlesphysicochemical propertiesprotein coronatoxicology

More Related Videos

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
14:53

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

Published on: February 3, 2018

7.4K
Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.5K

Related Experiment Videos

Last Updated: Dec 11, 2025

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
07:08

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

7.8K
In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
14:53

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

Published on: February 3, 2018

7.4K
Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.5K

Area of Science:

  • Environmental Science
  • Toxicology
  • Materials Science

Background:

  • Nanoparticles are ubiquitous in the environment from natural and anthropogenic sources.
  • Human exposure to nanoparticles is inevitable, necessitating an understanding of their health effects.
  • Assessing potential acute and chronic adverse effects is critical.

Purpose of the Study:

  • To review the current state of nanotoxicology research.
  • To focus on the mechanistic understanding of nanoparticle toxicity at multiple biological levels.
  • To identify approaches for advancing the field and ensuring safe nanotechnology applications.

Main Methods:

  • Review of existing literature on nanotoxicology.
  • Analysis of key nanotoxicity mechanisms.
  • Discussion of biological interactions from organ to biomolecular levels.

Main Results:

  • Identified key nanotoxicity mechanisms: reactive oxygen species generation, nanoparticle disintegration, cell signaling modulation, protein corona formation, and PEG-mediated immunogenicity.
  • Highlighted the importance of understanding toxicity at organ, tissue, cell, and biomolecular levels.
  • Emphasized the need for mechanistic insights to develop mitigation strategies.

Conclusions:

  • Improved understanding of nanoparticle toxicity is essential for safe human applications.
  • Advances in nanotoxicology research will inform regulatory frameworks for nanotechnology.
  • The goal is to harness nanotechnology's potential while minimizing risks to human health.