[A Meta-analysis of cochlear implantation in deafness patients with Mondini malformation]

Objective:To compare the efficacy of cochlear implantation in deaf patients with Mondini malformation and normal anatomical structure of inner ear, and to determine whether cochlear implantation can be an effective way to reconstruct hearing in hearing loss patients with Mondini malformation, so as to guide clinical work. Method:Literature search was conducted on PubMed, YZ365. com, Wip medicine, Wanfang data, CHKD, CNKI and other electronic databases to search case control studies on postoperative rehabilitation effect of deafness patients with Mondini deformity and normal structure of inner ear. Execute Meta-analysis by using RevMan 5.3 software. Result:Eleven articles were included and 1 371 patients were involved. Meta-analysis showed that the probability of Mondini abnormalities in patients with intraoperative complications（Z=6.62, P<0.01）, electrode reaction T value（Z=6.08, P<0.01）, postoperative hearing threshold（500 Hz, 1 000 Hz and 2 000 Hz） is greater than the control group, neural response telemetry（Z=3.44, P<0.01） and categories of auditory performance score（Z=5.27, P<0.01） is lower than the control group, about postoperative complications（Z=1.01, P>0.05） and speech intelligibility rating score（Z=1.41, P>0.05） there was no statistically significant difference with the control group. Conclusion:Cochlear implantation can be a mean of treatment and rehabilitation for deafness patients with Mondini deformity, and is necessary for hearing reconstruction. Further multi-parameter controlled studies with longer follow-up periods and larger samples will increase the credibility for the efficacy of cochlear implants in deafness patients with Mondini malformation.