Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis

The resistance exercise has drawn considerable attention to the level of insulin-like growth factor 1 in the serum. However, the relationship between resistance exercise and the level of insulin-like growth factor 1 in the serum is conflicting. This meta-analysis was performed to evaluate this relationship.

A systematic literature search up to May 2020 was performed and 22 studies were detected with 680 subjects. They reported relationships between resistance exercise and the level of insulin-like growth factor 1 in the serum. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated comparing the resistance exercise and the level of insulin-like growth factor 1 in the serum using the continuous method with a random or fixed-effect model.

Significantly higher insulin-like growth factor 1 was observed in subjects performing resistance training for less than 16 weeks (OR, 4.03; 95% CI, 2.49-5.57, p<.001); subjects performing resistance training for more than 16 weeks (OR, 11.55; 95% CI, 6.58-16.52, p<.001); subjects older than 60 years (OR, 11.88; 95% CI, 9.84-13.93, p<.001); females (OR, 3.87; 95% CI, 2.26-5.49, p<.001) and males (OR, 16.82; 95% CI, 7.29-26.35, p<.001). However, significantly lower insulin-like growth factor 1 was observed in subjects younger than 60 years (OR, -4.80; 95% CI, -7.74 to -1.86, p=.001).

However, the resistance exercise significantly increases insulin-like growth factor 1 in subjects older than 60 years, both males and females, and subjects performing resistance exercise for all any period. Surprisingly, resistance exercise significantly decreases insulin-like growth factor 1 in subjects younger than 60 years. This relationship forces us to recommend the resistance exercise to improve insulin-like growth factor 1 in serum.