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Updated: Dec 10, 2025
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
12.8K
[PIGMENTED BASAL CELL CARCINOMA AND IONIZING RADIATION]
Mati Rozenblat1, Ofer Mor1, Amro Bladsee1
1Department of Dermatology, "Emek" Medical Center, Afula, Israel.
Harefuah
|August 28, 2020
Summary
Ionizing radiation exposure may alter the characteristics of pigmented basal cell carcinoma (BCC). Patients treated with radiation showed a higher rate of well-differentiated tumors compared to controls.
Area of Science:
- Dermatology
- Oncology
- Radiation Oncology
Background:
- Chronic exposure to ionizing radiation is linked to increased morbidity.
- Basal cell carcinoma (BCC) has known associations with ionizing radiation.
- Specific characteristics of pigmented BCC in relation to prior radiation exposure are not well-documented.
Purpose of the Study:
- To investigate differences in histological and clinical manifestations of pigmented BCC.
- To compare pigmented BCC in patients previously treated with ionizing radiation for ringworm versus those without such treatment.
Main Methods:
- Retrospective analysis of 23 patients with pigmented BCC treated with ionizing radiation for ringworm.
- Comparison with a control group of 21 patients with pigmented BCC not treated with ionizing radiation.
- Data collected between 2005-2015 and analyzed using SPSS.
Main Results:
- A significantly higher percentage of well-differentiated tumors (34.8%) was observed in the ionizing radiation-treated group compared to the control group (14.3%).
- The average age of patients in the ionizing radiation-treated group was 66, versus 73 in the control group.
Conclusions:
- Pigmented basal cell carcinoma exhibits distinct characteristics in patients with a history of ionizing radiation treatment.
- These findings suggest a potential influence of prior radiation exposure on the presentation of pigmented BCC.
- Further research is warranted to validate and expand upon these observations.
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