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Updated: Dec 10, 2025

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
Published on: December 20, 2021
Nuclear actin in cancer biology
1Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany.
Abstract:
The presence of actin in the nucleus has been a matter of debate for many years. In recent years many important roles of actin in the nucleus (transcriptional regulation, chromatin remodeling, DNA repair, cell division, maintenance of nuclear architecture) have been identified, and the precise control of nuclear actin levels has been demonstrated. The vital importance of the actin driven processes in the cell make it highly likely that dysregulation of nuclear actin dynamics and structure can be linked to tumor induction and -progression. In this chapter I summarize our current knowledge about nuclear actin in the cancer context.
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