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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Commitment is the  process whereby stem cells:
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Overview of Hematopoiesis01:20

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
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Hematopoietic Reprogramming Entangles with Hematopoiesis.

Chuijin Wei1, Pei Yu2, Lin Cheng1

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Trends in Cell Biology
|August 31, 2020
PubMed
Summary
This summary is machine-generated.

Hematopoietic reprogramming reveals that blood cell development is reversible and interconvertible. This process, influenced by transcription factors and cytokines, offers potential for cell therapy and understanding blood disorders.

Keywords:
cell dedifferentiationcell reprogrammingcell transdifferentiationhematopoiesis

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Cellular Reprogramming

Background:

  • Hematopoiesis, the development of blood cells, was traditionally viewed as a unidirectional process.
  • Recent findings indicate that hematopoietic processes are reversible and interconvertible through cell reprogramming.

Purpose of the Study:

  • To explore hematopoietic reprogramming, encompassing both natural and induced processes.
  • To investigate the roles of transcription factors, chemical compounds, and cytokines in directing these changes.

Main Methods:

  • Review of existing literature on hematopoietic reprogramming.
  • Analysis of factors influencing cell reprogramming in physiological and pathological contexts.

Main Results:

  • Hematopoietic reprogramming demonstrates the plasticity of blood cell development.
  • Identified key molecular drivers including transcription factors, chemical compounds, and cytokines.

Conclusions:

  • Understanding hematopoietic reprogramming is crucial for advancing cell therapy applications.
  • This knowledge aids in analyzing normal and malignant hematopoiesis for better disease insights.