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Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Visual Function Endpoints to Enable Dry AMD Clinical Trials.

Luis Andres Lesmes^1,2, Mary Lou Jackson^3,2, Peter Bex^1,3,2

¹Schepens Eye Research Institute, 20 Staniford St, Boston, MA, United States.

Drug Discovery Today. Therapeutic Strategies

|September 1, 2020

Summary

This summary is machine-generated.

Developing new treatments for non-exudative age-related macular degeneration (dry AMD) requires better ways to measure vision. This review explores visual function tests like contrast sensitivity and reading speed as improved endpoints for clinical trials.

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Last Updated: Dec 10, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

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Published on: February 11, 2014

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Area of Science:

Ophthalmology
Clinical Trial Design
Drug Discovery

Background:

Non-exudative age-related macular degeneration (dry AMD) progresses slowly, posing challenges for drug discovery.
Current standard endpoints, such as best-corrected visual acuity, lack sensitivity for early-stage dry AMD.

Purpose of the Study:

To review and identify promising visual function endpoints for dry AMD clinical trials.
To highlight the need for novel endpoints to facilitate effective drug discovery for dry AMD.

Main Methods:

Literature review of visual function assessments.
Analysis of potential endpoints for clinical trial application in dry AMD.

Main Results:

Contrast sensitivity, reading speed, microperimetry, and dark adaptation are identified as promising visual function endpoints.
These assessments offer greater sensitivity to early changes in dry AMD compared to traditional measures.

Conclusions:

Adoption of these novel endpoints is critical for future dry AMD drug discovery.
Further determination of accuracy, precision, and applicability is necessary to validate their value.