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Published on: December 19, 2020
Clinical Features of COVID-19 Patients in Xiaogan City
Gong Feng1, Wan-Qiang Huang2, Man-Ling Liu1
1Xi'an Medical University, Xi'an, China.
Insights
This study found that older age and elevated C-reactive protein (CRP) levels are linked to increased COVID-19 severity. Healthcare providers should monitor these risk factors for better patient outcomes.
Area of Science:
- Medicine
- Epidemiology
- Public Health
Background:
- Xiaogan City was severely impacted by COVID-19 in early 2020.
- Understanding clinical features and risk factors is crucial for managing the pandemic.
Purpose of the Study:
- To investigate the clinical characteristics of COVID-19 patients in Xiaogan.
- To assess the association between COVID-19 severity, patient age, and C-reactive protein (CRP) levels.
Main Methods:
- Retrospective analysis of 134 hospitalized COVID-19 patients from February 1 to March 1, 2020.
- Collection of clinical data including symptoms, incubation period, and treatments.
- Statistical analysis to determine correlations between age, CRP levels, and disease severity.
Main Results:
- The most common symptoms were fever (66.4%), cough (33.6%), and sore throat (14.7%).
- COVID-19 severity showed a positive correlation with both increasing age and elevated CRP levels (P < 0.05).
- Only 5 out of 134 patients required intensive care, and 2 patients died.
Conclusions:
- Clinical presentation of COVID-19 in this cohort was generally moderate.
- Elderly patients and those with high CRP levels face a higher risk of progressing to severe COVID-19.
- Awareness of these factors is vital for healthcare professionals in managing COVID-19 patients.
Abstract:
On February 6, 2020, Xiaogan City became the second most seriously affected city with coronavirus disease 2019 (COVID-19), outside Wuhan district, Hubei Province, China. The objectives are to study the clinical features of COVID-19 patients and assess the relationship between the severity of COVID-19, age, and C-reactive protein (CRP) levels. The retrospective data of 134 COVID-19 patients hospitalized in 3 hospitals of Xiaogan City, between February 1 and March 1, 2020, was collected. This study documented COVID-19 patients. Clinical data in terms of body temperature, history of travel, and direct contact with COVID-19 patients, and incubation period was collected. Out of the 134 patients, only 5 required intensive care. Moreover, 2 patients succumbed during this period. The median age of patients was 45 (33-56) years. The most common symptoms at the onset of disease were fever (66.4%), cough (33, 6%), and sore throat (14.7%). Amongst the medicines used, antiviral agents (92.3%) followed by the traditional Chinese medicine (89.5%) were most commonly used. In both the crude and adjusted (I to III) models, odds ratio and its 95% confidence interval for both age and CRP levels were > 1. Moreover, the smooth curve fitting graph reflected that the severity of COVID-19 was positively correlated with both age and CRP levels (all P value < 0.05). The signs and symptoms of COVID-19 patients were fairly moderate. The health care professionals treating the COVID-19 patients should be aware of the increased likelihood of progression to severe COVID-19 in elderly patients and those with high CRP levels.
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